Advances in Chronic Kidney Disease
Volume 11, Issue 3 , Pages 319-327, July 2004

The spectrum of cardiovascular disease in children with predialysis chronic kidney disease

  • Blanche M Chavers

      Affiliations

    • Division of Nephrology, Department of Pediatrics, Hennepin County Medical Center; University of Minnesota, Minneapolis, MN, USA
    • Corresponding Author InformationAddress correspondence to Blanche Chavers, MD, University of Minnesota, Department of Pediatrics, Division of Pediatric Nephrology, 420 Delaware Street SE, MMC 491, Minneapolis, MN 55455 USA
    • ,
  • Charles A Herzog

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Hennepin County Medical Center; University of Minnesota, Minneapolis, MN, USA

Abstract 

Cardiovascular disease is the major cause of mortality in adults and children on chronic dialysis and in adults after kidney transplantation. Cardiovascular disease burden and cardiovascular mortality are high in adults with chronic kidney disease. The early development of cardiovascular disease risk factors, some of which are modifiable, largely explain this phenomenon. Limited data are available on the prevalence of chronic kidney disease in children, the prevalence of cardiovascular disease in children with chronic kidney disease, and the prevalence of cardiovascular disease risk factors in these patients. This article summarizes the current knowledge of the prevalence of cardiovascular disease and of cardiovascular disease risk factors in pediatric patients with predialysis chronic kidney disease. Long-term prospective studies are needed to determine the impact of early identification and treatment of cardiovascular disease and its risk factors on the natural history of cardiovascular disease in children with chronic kidney disease.

Keywords:  Pediatric, cardiovascular disease, chronic kidney disease, risk factors, anemia, hypertension, dyslipidemia

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PII: S1548-5595(04)00071-0

doi:10.1053/j.arrt.2004.04.002

Advances in Chronic Kidney Disease
Volume 11, Issue 3 , Pages 319-327, July 2004

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