Hypertension in Children with Chronic Kidney Disease

Hypertension occurs commonly in children with chronic kidney disease (CKD) and undoubtedly contributes to the progression of disease. This review summarizes the role of hypertension in the progression of CKD in children and highlights the central role played by the renin-angiotensin system in this relentless process. Strategies for renoprotection are discussed, and treatment recommendations are made for control of hypertension in this patient population.

Index Words: Hypertension , Chronic kidney disease , Children , Adolescents

a Section of Pediatric Nephrology, Children’s Hospital at Montefiore, Montefiore Medical Center, Bronx, NY, USA

b Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA

Address correspondence to Joseph T. Flynn, MD, MS, Division of Pediatric Nephrology, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467

PII: S1548-5595(05)00115-1

doi:10.1053/j.ackd.2005.07.002

12 of 21