Advances in Chronic Kidney Disease
Volume 13, Issue 2 , Pages 155-165 , April 2006

Renal Phosphate–Wasting Disorders

  • Moshe Levi

      Affiliations

    • Departments of Medicine, Physiology and Biophysics, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO
    • Corresponding Author InformationAddress correspondence to Moshe Levi, MD, Departments of Medicine, Physiology and Biophysics, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262.
    • ,
  • Judith Blaine

      Affiliations

    • Departments of Medicine, Physiology and Biophysics, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO
    • ,
  • Sophia Breusegem

      Affiliations

    • Departments of Medicine, Physiology and Biophysics, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO
    • ,
  • Hideaki Takahashi

      Affiliations

    • Departments of Medicine, Physiology and Biophysics, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO
    • ,
  • Victor Sorribas

      Affiliations

    • Department of Toxicology, University of Zaragoza, Zaragoza, Spain.
    • ,
  • Nicholas Barry

      Affiliations

    • Departments of Medicine, Physiology and Biophysics, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO

References 

  1. Murer H , Forster I , Biber J . The sodium phosphate cotransporter family SLC34 . Pflugers Arch . 2004;447:763–767
  2. Miyamoto K , Segawa H , Ito M , et al.   Physiological regulation of renal sodium-dependent phosphate cotransporters . Jpn J Physiol . 2004;54:93–102
  3. Tenenhouse HS . Regulation of phosphorus homeostasis by the type IIa Na/phosphate cotransporter . Annu Rev Nutr . 2005;25:197–214
  4. Kavanaugh MP , Kabat D . Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor family . Kidney Int . 1996;49:959–963
  5. Hernando N , Gisler SM , Pribanic S , et al.   NaPi-IIa and interacting proteins . J Physiol . 2005;567:21–26
  6. McWilliams RR , Breusegem SY , Brodsky KF , et al.   Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells . Am J Physiol Cell Physiol . 2005;289:C1042–C1051
  7. Berndt TJ , Schiavi S , Kumar R . “Phosphatonins” and the regulation of phosphorus homeostasis . Am J Physiol Renal Physiol . 2005;289:F1170–F1182
  8. HYP Consortium (A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets) . Nat Genet . 1995;11:130–136
  9. ADHR Consortium (Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF-23) . Nat Genet . 2000;26:345–348
  10. Larsson T , Marsell R , Schipani E , et al.   Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis . Endocrinology . 2004;145:3087–3094
  11. Shimada T , Hasegawa H , Yamazaki Y , et al.   FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis . J Bone Miner Res . 2004;19:429–435
  12. Shimada T , Kakitani M , Yamazaki Y , et al.   Targeted ablation of FGF-23 demonstrates an essential physiological role of FGF-23 in phosphate and vitamin D metabolism . J Clin Invest . 2004;113:561–568
  13. De Beur SM , Finnegan RB , Vassiliadis J , et al.   Tumors associated with oncogenic osteomalacia express genes important in bone and mineral metabolism . J Bone Miner Res . 2002;17:1102–1110
  14. Berndt TJ , Bielesz B , Craig TA , et al.   Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells . Pflugers Arch . 2006;45:579–587
  15. Rowe PS . The wrickkened pathways of FGF-23, MEPE and PHEX . Crit Rev Oral Biol Med . 2004;15:264–281
  16. Riminucci M , Collins MT , Fedarko NS , et al.   FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting . J Clin Invest . 2003;112:683–692
  17. Prie D , Beck L , Urena P , et al.   Recent findings in phosphate homeostasis . Curr Opin Nephrol Hypertens . 2005;14:318–324
  18. Bergwitz C , Roslin NM , Tieder M , et al.   SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis . Am J Hum Genet . 2006;78:179–192
  19. Topaz O , Shurman DL , Bergman R , et al.   Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis . Nat Genet . 2004;36:579–581
  20. Chefetz I , Heller R , Galli-Tsinopoulou A , et al.   A novel homozygous missense mutation in FGF-23 causes familial tumoral calcinosis associated with disseminated visceral calcification . Hum Genet . 2005;118:261–266

PII: S1548-5595(06)00013-9

doi: 10.1053/j.ackd.2006.01.012

Advances in Chronic Kidney Disease
Volume 13, Issue 2 , Pages 155-165 , April 2006

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