Advances in Chronic Kidney Disease
Volume 14, Issue 1 , Pages 54-66, January 2007

Mechanisms of Vascular Calcification

Department of Bioengineering, University of Washington, Seattle, WA.

Vascular calcification is highly prevalent and correlated with high rates of cardiovascular mortality in chronic kidney disease patients. Recent evidence suggests that mineral, hormonal, and metabolic imbalances that promote phenotype change in vascular cells as well as deficiencies in specific mineralization inhibitory pathways may be important contributory factors for vascular calcification in these patients. This article reviews current mechanisms proposed for the regulation of vascular calcification and data supporting their potential contribution to this process in chronic kidney disease.

Index Words: Vascular calcification, Phosphate, Calcium, Smooth muscle, Chronic kidney disease

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 Supported in part by NIH grants HL62329 and HL081785.

PII: S1548-5595(06)00169-8

doi:10.1053/j.ackd.2006.10.007

Advances in Chronic Kidney Disease
Volume 14, Issue 1 , Pages 54-66, January 2007

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