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Advances in Chronic Kidney Disease
Volume 14, Issue 1
, Pages 54-66
, January 2007
Mechanisms of Vascular Calcification
References
- Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia. Curr Opin Nephrol Hypertens. 2005;14:525–531
- . Pathophysiology of vascular calcification in chronic kidney disease. Circ Res. 2004;95:560–567
- . Cardiovascular calcifications in uremic patients: Clinical impact on cardiovascular function. J Am Soc Nephrol. 2003;14:S305–S309
- Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study. Am J Kidney Dis. 1998;31:607–617
- Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol. 2004;15:2208–2218
- Predictors and consequences of altered mineral metabolism: the Dialysis Outcomes and Practice Patterns Study. Kidney Int. 2005;67:1179–1187
- Phosphate overload accelerates vascular calcium deposition in end-stage renal disease patients. Nephrol Dial Transplant. 2003;18:iii86–iii89
- Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med. 2000;342:1478–1483
- . Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int. 2002;62:245–252
- The effects of sevelamer and calcium acetate on proxies of atherosclerotic and arteriosclerotic vascular disease in hemodialysis patients. Am J Nephrol. 2003;23:307–314
- . Phosphorus restriction and control of coronary calcification as assessed by electron beam tomography. Curr Opin Nephrol Hypertens. 2002;11:391–395
- Smooth muscle cell phenotypic transition associated with calcification: Upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res. 2001;89:1147–1154
- Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells. Kidney Int. 2002;62:1724–1731
- Phosphate regulation of vascular smooth muscle cell calcification. Circ Res. 2000;87:E10–E17
- Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1995;15:2003–2009
- Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism. Nephrol Dial Transplant. 2006;21:911–916
- Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol. 2003;23:489–494
- . Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. Circ Res. 2006;98:905–912
- Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: An integrated model of the pathogenesis of mineralization disorders. Am J Pathol. 2004;164:1199–1209
- Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation (A possible explanation for the paradox of arterial calcification in osteoporotic patients). Arterioscler Thromb Vasc Biol. 1997;17:680–687
- Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation. 2000;102:2636–2642
- . Mechanism of calcification: Inhibitory role of pyrophosphate. Nature. 1962;195:911
- . Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol. 2001;281:C1–C11
- Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1-/- mice. Arterioscler Thromb Vasc Biol. 2005;25:686–691
- . Inorganic pyrophosphate: A paracrine regulator of vascular calcification and smooth muscle phenotype. Arterioscler Thromb Vasc Biol. 2005;25:651–654
- . Reduced plasma pyrophosphate levels in hemodialysis patients. J Am Soc Nephrol. 2005;16:2495–2500
- Adult hypophosphatasia (Current aspects). Joint Bone Spine. 2001;68:120–124
- Mutations in ENPP1 are associated with ‘idiopathic’ infantile arterial calcification. Nat Genet. 2003;34:379–381
- Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. J Bone Miner Res. 2003;18:994–1004
- . Calcium loading, calcium accumulation, and associated cardiovascular risks in dialysis patients. Blood Purif. 2005;23:12–19
- Two year comparison of sevelamer and calcium carbonate effects on cardiovascular calcification and bone density. Nephrol Dial Transplant. 2005;20:1653–1661
- . Slowing the progression of vascular calcification in hemodialysis. J Am Soc Nephrol. 2003;14:S310–S314
- Long-term comparison of a calcium-free phosphate binder and calcium carbonate–phosphorus metabolism and cardiovascular calcification. Clin Nephrol. 2004;62:104–115
- Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis. Kidney Int. 2005;68:1815–1824
- . The role of sevelamer in achieving the kidney disease outcomes quality initiative (K/DOQI) guidelines for hyperphosphatemia. Curr Med Res Opin. 2004;20:991–999
- Systemic cardiovascular disease in uremic rats induced by 1,25(OH)2D3. J Hypertens. 2005;23:1067–1075
- . Hypercalcemia and metastatic calcification. Cardiovasc Res. 1997;36:293–297
- . Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int. 2004;66:2293–2299
- Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: A potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol. 2004;15:2857–2867
- Vitamin D insufficiency and deficiency in chronic kidney disease (A single center observational study). Am J Nephrol. 2004;24:503–510
- Calcium metabolism in early chronic renal failure: Implications for the pathogenesis of hyperparathyroidism. Nephrol Dial Transplant. 1991;6:162–169
- Management of disturbances of calcium and phosphate metabolism in chronic renal insufficiency, with emphasis on the control of hyperphosphataemia. Nephrol Dial Transplant. 2002;17:723–731
- . Medical management of secondary hyperparathyroidism in chronic renal failure. Nephrol Dial Transplant. 2003;18:iii2–iii28
- Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol. J Am Soc Nephrol. 2006;17:795–804
- Effect of etidronate on aortic calcification and bone metabolism in calcitriol-treated rats with subtotal nephrectomy. J Pharmacol Sci. 2005;99:89–94
- In subtotally nephrectomized rats 22-oxacalcitriol suppresses parathyroid hormone with less risk of cardiovascular calcification or deterioration of residual renal function than 1,25(OH)2 vitamin D3. Nephrol Dial Transplant. 2003;18:1770–1776
- Cardiovascular disease in chronic kidney failure: the role of VDR activators. Curr Opin Investig Drugs. 2006;7:206–213
- Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N Engl J Med. 2003;349:446–456
- Induction of bone-type alkaline phosphatase in human vascular smooth muscle cells: Roles of tumor necrosis factor-alpha and oncostatin M derived from macrophages. Circ Res. 2002;91:9–16
- 1,25-Dihydroxyvitamin D3 increases in vitro vascular calcification by modulating secretion of endogenous parathyroid hormone-related peptide. Circulation. 1998;98:1302–1306
- . The role of vitamin D in vascular calcification in chronic kidney disease. Semin Dial. 2005;18:307–314
- . Pathogenesis of secondary hyperparathyroidism. Kidney Int Suppl. 1999;73:S14–S19
- Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation. 2002;106:100–105
- The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients. Nephrol Dial Transplant. 2006;21:2464–2471
- Severe hyperparathyroidism with bone abnormalities and metastatic calcification in rats with adenine-induced uraemia. Nephrol Dial Transplant. 2006;21:651–659
- Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients. Am J Kidney Dis. 1996;27:394–401
- Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells. Am J Kidney Dis. 2001;37:1267–1276
- Long-term outcomes in patients with calciphylaxis from hyperparathyroidism. Ann Surg Oncol. 2006;13:96–102
- Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice. J Biol Chem. 2003;278:50195–50202
- Parathyroid hormone-related peptide as a local regulator of vascular calcification (Its inhibitory action on in vitro calcification by bovine vascular smooth muscle cells). Arterioscler Thromb Vasc Biol. 1997;17:1135–1142
- FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res. 2004;19:429–435
- Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest. 2004;113:561–568
- An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet. 2005;14:385–390
- Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004;23:421–432
- Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390:45–51
- Regulation of fibroblast growth factor-23 signaling by Klotho. J Biol Chem. 2006;281:6120–6123
- Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int. 2003;64:2272–2279
- FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation. Nephron Physiol. 2006;104:23–32
- . With or without the kidney: the role of FGF23 in CKD. Nephrol Dial Transplant. 2005;20:1295–1298
- Arterial calcifications and bone histomorphometry in end-stage renal disease. J Am Soc Nephrol. 2004;15:1943–1951
- Progression of aortic calcification is associated with metacarpal bone loss during menopause: A population-based longitudinal study. Arterioscler Thromb Vasc Biol. 2000;20:1926–1931
- . Arterial calcification in diabetes. Curr Diab Rep. 2003;3:28–32
- . Diabetic nephropathy. In: Brenner S editors. The Kidney. Philadelphia, PA: Saunders; 2000;p. 1731
- MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors. J Biol Chem. 2003;278:45969–45977
- Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest. 2005;115:1210–1220
- . Molecular mechanisms of vascular calcification: Lessons learned from the aorta. Arterioscler Thromb Vasc Biol. 2006;26:1423–1430
- Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 1993;91:1800–1809
- High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J Clin Invest. 1994;93:2393–2402
- . [Measurement of serum MGP] Clin Calcium. 2002;12:1102–1104
- Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD). Kidney Int. 2005;67:2295–2304
- Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall. Biochem Biophys Res Commun. 2001;289:485–490
- Medial localization of mineralization-regulating proteins in association with Monckeberg’s sclerosis: Evidence for smooth muscle cell-mediated vascular calcification. Circulation. 1999;100:2168–2176
- Expression of matrix Gla protein (MGP) in an in vitro model of vascular calcification. FEBS Lett. 1998;433:19–22
- Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997;386:78–81
- A novel MGP mutation in a consanguineous family: Review of the clinical and molecular characteristics of Keutel syndrome. Am J Med Genet A. 2005;135:36–40
- Extracellular matrix mineralization is regulated locally: Different roles of two gla-containing proteins. J Cell Biol. 2004;165:625–630
- . Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterioscler Thromb Vasc Biol. 1998;18:1400–1407
- . Calciphylaxis and vascular calcification: A continuum of extra-skeletal osteogenesis. Pediatr Nephrol. 2003;18:969–975
- Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: Undercarboxylated matrix Gla protein as marker for vascular calcification. Arterioscler Thromb Vasc Biol. 2005;25:1629–1633
- Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. Thromb Haemost. 2004;91:790–794
- Characteristics and performance of an immunosorbent assay for human matrix Gla-protein. Clin Chim Acta. 2005;351:131–138
- . Bone origin of the serum complex of calcium, phosphate, fetuin, and matrix Gla protein: Biochemical evidence for the cancellous bone-remodeling compartment. J Bone Miner Res. 2002;17:1171–1179
- . Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2. J Biol Chem. 2002;277:4388–4394
- A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. J Biol Chem. 2001;276:32466–32473
- . Vitamin K epoxide reductase complex and vascular calcification: Is this the important link between vitamin K and the arterial vessel wall?. Circulation. 2006;113:1550–1552
- Role of matrix Gla protein in parathyroid hormone inhibition of osteoblast mineralization. Cells Tissues Organs. 2005;181:166–175
- Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor. Biochem Biophys Res Commun. 2000;277:736–740
- Transcriptional regulation of matrix gla protein. Z Kardiol. 2001;90:38–42
- The serum protein alpha2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells (A possible role in mineralization and calcium homeostasis). J Biol Chem. 1996;271:20789–20796
- Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: A cross-sectional study. Lancet. 2003;361:827–833
- Serum fetuin-A and aortic calcification in hemodialysis patients. Kidney Int. 2005;68:2915
- Cardiac calcifications: Fetuin-A and other risk factors in hemodialysis patients. ASAIO J. 2006;52:150–156
- Serum fetuin-A in nondialyzed patients with diabetic nephropathy: Relationship with coronary artery calcification. Kidney Int. 2005;67:1070–1077
- Fetuin-A and kidney function in persons with coronary artery disease—Data from the heart and soul study. Nephrol Dial Transplant. 2006;21:2144–2151
- Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. Kidney Int. 2005;67:2383–2392
- The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest. 2003;112:357–366
- Role of serum fetuin-A, a major inhibitor of systemic calcification, in pseudoxanthoma elasticum. Clin Chem. 2006;52:227–234
- Systemic inhibition of spontaneous calcification by the serum protein alpha 2-HS glycoprotein/fetuin. Z Kardiol. 2001;90:47–56
- Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats. J Biol Chem. 2002;277:3926–3934
- Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist. J Biol Chem. 1996;271:12755–12761
- Regulation of osteogenesis by fetuin. J Biol Chem. 1999;274:28514–28520
- Alpha2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor. Mol Cell Endocrinol. 2000;164:87–98
- Effects of rat fetuin on stimulation of bone resorption in the presence of parathyroid hormone. Biosci Biotechnol Biochem. 1999;63:1383–1391
- Posttranslational processing of human alpha 2-HS glycoprotein (human fetuin) (Evidence for the production of a phosphorylated single-chain form by hepatoma cells). Eur J Biochem. 1994;226:59–69
- . Bone morphogenetic proteins in vascular calcification. Circ Res. 2005;97:105–114
- . BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J Am Soc Nephrol. 2003;14:1559–1567
- Connections between vascular calcification and progression of chronic kidney disease: Therapeutic alternatives. Kidney Int Suppl. 2005;99:S142–S151
- . Bone morphogenetic protein-7 modulates genes that maintain the vascular smooth muscle cell phenotype in culture. J Bone Joint Surg Am. 2001;83A:S70–S78
- Kidney-bone, bone-kidney, and cell-cell communications in renal osteodystrophy. Semin Nephrol. 2004;24:25–38
- . Treatment of soft tissue calcifications with magnesium. Acta Univ Palacki Olomuc Fac Med. 1991;130:273–287
- Renal cortical calcification in syngeneic intact rats and those receiving an infrarenal thoracic aortic graft: Possible etiological roles of endothelin, nitrate and minerals, and different preventive effects of long-term oral treatment with magnesium, citrate and alkali-containing preparations. Urol Res. 2001;29:229–237
- . Effect of dietary magnesium on the development of nephrocalcinosis in rats. J Nutr. 1969;97:353–358
- Proceedings: Effect of magnesium on secondary hyperparathyroidism in chronic hemodialysis: A case with soft tissue calcification improved by high Mg dialysate. Calcif Tissue Res. 1974;15:162
- Initiation and inhibition of subcutaneous calcification. Calcif Tissue Res. 1972;10:269–279
- . Magnesium, the mimic/antagonist to calcium. N Engl J Med. 1984;310:1253–1255
- Mg2+: A potent inhibitor of collagen-induced in vitro mineralization. Magnes Res. 2004;17:67–71
- . The effect of some inhibitors on the nucleation and crystal growth of apatite. Calcif Tissue Res. 1969;3:348–357
- Influence of magnesium deficiency on concentration of calcium in soft tissue of uremic rats. Ren Fail. 1996;18:847–854
- Media calcification, low erythrocyte magnesium, altered plasma magnesium, and calcium homeostasis following grafting of the thoracic aorta to the infrarenal aorta in the rat—Differential preventive effects of long-term oral magnesium supplementation alone and in combination with alkali. Biomed Pharmacother. 2003;57:88–97
- . Effects of a dietary magnesium deficiency and excess vitamin D3 on swine coronary arteries. J Am Coll Nutr. 1990;9:155–163
- . Coronary arterial lesions in Mg-deficient hamsters. Magnesium. 1985;4:82–95
- . Role of magnesium and potassium in the pathogenesis of arteriosclerosis. Magnesium. 1984;3:226–238
- . Serum magnesium level and arterial calcification in end-stage renal disease. Kidney Int. 1987;32:388–394
- Relationship between serum magnesium, parathyroid hormone, and vascular calcification in patients on dialysis: A literature review. Perit Dial Int. 2006;26:366–373
- Relationship between serum magnesium and parathyroid hormone levels in hemodialysis patients. Am J Kidney Dis. 1999;34:43–48
- . Parathyroid hormone secretion in vitro: Regulation by calcium and magnesium ions. Nature. 1970;225:1056–1058
- . Comparison of the feedback effect of magnesium and calcium on parathyroid hormone secretion in man. J Endocrinol. 1987;113:117–122
- . The effects of calcium and magnesium of PTH secretion. Ariz Med. 1971;28:263
- The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. N Engl J Med. 1984;310:1221–1225
- . Serum magnesium and parathyroid hormone levels in dialysis patients. Kidney Int. 2000;57:2654
- Parathyroid hormone gene polymorphism and secondary hyperparathyroidism in hemodialysis patients. Am J Kidney Dis. 2002;39:1255–1260
- Effect of hypermagnesemia on circulating plasma parathyroid hormone in patients on regular hemodialysis therapy. Magnesium. 1984;3:1–7
- . The essentials of calcium, magnesium and phosphate metabolism: Part I (Physiology). Crit Care Resusc. 2002;4:301–306
- . Acute effects of different concentrations of dialysate magnesium during high-efficiency dialysis. Am J Kidney Dis. 1994;24:453–460
- Atherogenic lipoproteins in end-stage renal disease. Am J Kidney Dis. 2001;38:S30–S33
- Significant association between the progression of coronary artery calcification and dyslipidemia in patients on chronic hemodialysis. Am J Kidney Dis. 2001;38:64–69
- Prevalence and correlates of coronary calcification in black and white young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Arterioscler Thromb Vasc Biol. 2001;21:852–857
- Effect of HMG-CoA reductase inhibitors on coronary artery disease as assessed by electron-beam computed tomography. N Engl J Med. 1998;339:1972–1978
- Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J Biol Chem. 1998;273:30427–30434
- Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease. Kidney Int. 2005;68:2608–2620
- Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway. J Biol Chem. 2005;280:32317–32325
- High-density lipoprotein regulates calcification of vascular cells. Circ Res. 2002;91:570–576
- . Novel mechanisms in accelerated vascular calcification in renal disease patients. Curr Opin Nephrol Hypertens. 2002;11:437–443
- N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways. Circ Res. 2006;98:727–729
- Monocyte/macrophage regulation of vascular calcification in vitro. Circulation. 2002;105:650–655
- cAMP stimulates osteoblast-like differentiation of calcifying vascular cells (Potential signaling pathway for vascular calcification). J Biol Chem. 1998;273:7547–7553
- . Parathyroid hormone levels, calcium-channel blockers, and the dyslipidemia of nondiabetic hemodialysis patients. Ren Fail. 2005;27:163–169
- . Hyperphosphatemia in end-stage renal disease patients: Pathophysiological consequences. Kidney Int Suppl. 1999;73:S31–S37
- Magnitude and impact of abnormal mineral metabolism in hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis. 2004;44:34–38
- Determinants of progressive vascular calcification in haemodialysis patients. Nephrol Dial Transplant. 2004;19:1489–1496
- Low levels of urinary inorganic pyrophosphate indicating systemic pyrophosphate deficiency in a boy with idiopathic infantile arterial calcification. Acta Paediatr. 2000;89:1265–1269
- . Disorders of calcium, phosphorus, and magnesium. Am J Kidney Dis. 2005;45:213–218
- Multifunctional roles for serum protein fetuin-A in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol. 2005;16:2920–2930
- Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 1998;12:1260–1268
- Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler Thromb Vasc Biol. 2001;21:1610–1616
- Serum osteoprotegerin levels and the extent of vascular calcification in haemodialysis patients. Nephrol Dial Transplant. 2004;19:1886–1889
- Plasma osteoprotegerin is associated with mortality in hemodialysis patients. J Am Soc Nephrol. 2006;17:262–270
- 1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism. Nephrol Dial Transplant. 2005;20:1370–1377
- Serum 25(OH)-vitamin D levels and bone metabolism in patients on maintenance hemodialysis. Clin Nephrol. 2005;64:288–294
- Cardiac valve calcification as an important predictor for all-cause mortality and cardiovascular mortality in long-term peritoneal dialysis patients: A prospective study. J Am Soc Nephrol. 2003;14:159–168
- . Chemical and hormonal determinants of vascular calcification in vitro. Kidney Int. 2006;69:1464–1470
- . Role of phosphorus in the pathogenesis of secondary hyperparathyroidism. Am J Kidney Dis. 2001;37:S54–S57
- Progression of aortic valve calcification: Association with coronary atherosclerosis and cardiovascular risk factors. Circulation. 2001;104:1927–1932
- PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol. 2001;158:543–554
- Severely reduced production of Klotho in human chronic renal failure kidney. Biochem Biophys Res Commun. 2001;280:1015–1020
- Calcification of vascular smooth muscle cell cultures: Inhibition by osteopontin. Circ Res. 1999;84:166–178
- Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: Evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med. 2002;196:1047–1055
- Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol. 2002;161:2035–2046
- Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin. Calcif Tissue Int. 2005;76:307–315
- . Uremic vasculopathy. Semin Nephrol. 2004;24:413–416
- Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. Kidney Int. 2003;63:1003–1011
- Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins. Kidney Int. 2002;61:638–647
- Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2001;21:1998–2003
- The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells. Kidney Int. 2006;70:1046–1053
- . Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro. J Cell Physiol. 2000;184:37–45
- Blood serum levels of IL-2, IL-6, IL-8, TNF-alpha and IL-1beta in patients on maintenance hemodialysis. Cell Mol Immunol. 2006;3:151–154
Supported in part by NIH grants HL62329 and HL081785.
PII: S1548-5595(06)00169-8
doi: 10.1053/j.ackd.2006.10.007
© 2007 National Kidney Foundation, Inc. Published by Elsevier Inc All rights reserved.
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Advances in Chronic Kidney Disease
Volume 14, Issue 1
, Pages 54-66
, January 2007
