Advances in Chronic Kidney Disease
Volume 15, Issue 3 , Pages 314-320, July 2008

Bone Morphogenetic Protein 7 (BMP7): A Critical Role in Kidney Development and a Putative Modulator of Kidney Injury

  • Patrick Archdeacon

      Affiliations

    • Corresponding Author InformationAddress correspondence to Patrick Archdeacon, MD, Division of Nephrology and Hypertension, UNC Hospital, UNC Kidney Center, 7007-B Burnett-Womack, Campus Box 7155, Chapel Hill, NC 27599-7155.
  • ,
  • Randal K. Detwiler

Division of Nephrology and Hypertension, UNC Hospital, UNC Kidney Center, Chapel Hill, NC

Bone morphogenetic protein 7 (BMP7), a member of the tumor growth factor β superfamily, appears to have a role in both kidney development and response to kidney injury. Signals through its pathways permit both epithelial differentiation during embryogenesis and preservation of normal kidney architecture after stress, leading to the hypothesis that BMP7 may exert its kidney-protective effects in adult animals by preventing or reversing epithelial-to-mesenchymal transformation. This review attempts to synthesize the data supporting those conclusions and suggest some future areas of research.

Index Words: Bone morphogenetic protein 7, Epithelial-to-mesenchymal transformation, Interstitial fibrosis, Tumor growth factor β, Type I activin receptor-like kinase

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PII: S1548-5595(08)00058-X

doi:10.1053/j.ackd.2008.04.011

Advances in Chronic Kidney Disease
Volume 15, Issue 3 , Pages 314-320, July 2008