Advances in Chronic Kidney Disease
Volume 17, Issue 1 , Pages 83-93 , January 2010

CKD in HIV-Infected Patients Other Than HIV-Associated Nephropathy

  • Ajay K. Rachakonda
    • ,
  • Paul L. Kimmel

      Affiliations

    • Corresponding Author InformationAddress correspondence to Paul L. Kimmel, MD, Division of Kidney Urologic and Hematologic Diseases, National Institute of Diabetes, Digestive, and Kidney Diseases, 6707 Democracy Boulevard, Bethesda, MD 20892.

References 

  1. Lima VD, Hogg RS, Harrigan PR, et al. Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy. AIDS. 2007;21:685–692
  2. Crum NF, Riffenburgh RH, Wegner S, et al. Comparisons of causes of death and mortality rates among HIV-infected persons: analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) eras. J Acquir Immune Defic Syndr. 2006;41:194–200
  3. Eggers PW, Kimmel PL. Is there an epidemic of HIV Infection in the US ESRD program?. J Am Soc Nephrol. 2004;15:2477–2485
  4. Palella FJ, Baker RK, Moorman AC, et al. Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study. J Acquir Immune Defic Syndr. 2006;43:27–34
  5. Fine DM, Perazella MA, Lucas GM, et al. Renal disease in patients with HIV infection: Epidemiology, pathogenesis and management. Drugs. 2008;68:963–980
  6. Kimmel PL, Barisoni L, Kopp JB. Pathogenesis and treatment of HIV-associated renal diseases: Lessons from clinical and animal studies, molecular pathologic correlations, and genetic investigations. Ann Intern Med. 2003;139:214–226
  7. Weiner NJ, Goodman JW, Kimmel PL. The HIV-associated renal diseases: Current insight into pathogenesis and treatment. Kidney Int. 2003;63:1618–1631
  8. Wyatt CM, Klotman PE. HIV-associated nephropathy in the era of antiretroviral therapy. Am J Med. 2007;120:488–492
  9. Wyatt CM, Klotman PE. HIV-1 and HIV-associated nephropathy 25 years later. Clin J Am Soc Nephrol. 2007;2(suppl 1):S20–S24
  10. D'Agati V, Appel GB. HIV infection and the kidney. J Am Soc Nephrol. 1997;8:138–152
  11. Gardenswartz MH, Lerner CW, Seligson GR, et al. Renal disease in patients with AIDS: a clinicopathologic study. Clin Nephrol. 1984;21:197–204
  12. Pardo V, Aldana M, Colton RM, et al. Glomerular lesions in the acquired immunodeficiency syndrome. Ann Intern Med. 1984;101:429–434
  13. Rao TK, Filippone EJ, Nicastri AD, et al. Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome. N Engl J Med. 1984;310:669–673
  14. Cohen SD, Kimmel PL. Immune complex renal disease and human immunodeficiency virus infection. Semin Nephrol. 2008;28:535–544
  15. Kimmel PL, Ferreira-Centeno A, Farkas-Szallasi T, et al. Viral DNA in microdissected renal biopsy tissue from HIV infected patients with nephrotic syndrome. Kidney Int. 1993;43:1347–1352
  16. Hedayati SS, Reddan DN, Szczech LA. HIV-associated nephropathy: A review of the epidemiology and clinical course in the HAART era. AIDS Patient Care STDS. 2003;17:57–63
  17. Korbet SM, Schwartz MM. Human immunodeficiency virus infection and nephrotic syndrome. Am J Kidney Dis. 1992;20:97–103
  18. Nochy D, Glotz D, Dosquet P, et al. Renal disease associated with HIV infection: A multicentric study of 60 patients from Paris hospitals. Nephrol Dial Transplant. 1993;8:11–19
  19. Ortiz-Butcher C. The spectrum of kidney diseases in patients with human immunodeficiency virus infection. Curr Opin Nephrol Hypertens. 1993;2:355–364
  20. Rao TK. Renal complications in HIV disease. Med Clin North Am. 1996;80:1437–1451
  21. Rao TK, Friedman EA, Nicastri AD. The types of renal disease in the acquired immunodeficiency syndrome. N Engl J Med. 1987;316:1062–1068
  22. Szczech LA. Renal diseases associated with human immunodeficiency virus infection: Epidemiology, clinical course, and management. Clin Infect Dis. 2001;33:115–119
  23. Szczech LA, Gupta SK, Habash R, et al. The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infection. Kidney Int. 2004;66:1145–1152
  24. Cohen AH, Sun NC, Shapshak P, et al. Demonstration of human immunodeficiency virus in renal epithelium in HIV-associated nephropathy. Mod Pathol. 1989;2:125–128
  25. D'Agati V, Suh JI, Carbone L, et al. Pathology of HIV-associated nephropathy: A detailed morphologic and comparative study. Kidney Int. 1989;35:1358–1370
  26. Bourgoignie JJ, Meneses R, Ortiz C, et al. The clinical spectrum of renal disease associated with human immunodeficiency virus. Am J Kidney Dis. 1988;12:131–137
  27. Kimmel PL. Renal diseases in patients with HIV infection: A spectrum of outcomes in search of understanding. AIDS Read. 1999;9:25–27
  28. Kimmel PL, Phillips TM, Ferreira-Centeno A, et al. HIV-associated immune-mediated renal disease. Kidney Int. 1993;44:1327–1340
  29. Moake JL. Thrombotic microangiopathies. N Engl J Med. 2002;347:589–600
  30. Churg J, Strauss L. Renal involvement in thrombotic microangiopathies. Semin Nephrol. 1985;5:46–56
  31. Droz D, Nochy D, Noel LH, et al. Thrombotic microangiopathies: Renal and extrarenal lesions. Adv Nephrol Necker Hosp. 2000;30:235–259
  32. Fine DM, Fogo AB, Alpers CE. Thrombotic microangiopathy and other glomerular disorders in the HIV-infected patient. Semin Nephrol. 2008;28:545–555
  33. Becker S, Fusco G, Fusco J, et al. HIV-associated thrombotic microangiopathy in the era of highly active antiretroviral therapy: An observational study. Clin Infect Dis. 2004;39(suppl 5):S267–S275
  34. Berliner AR, Fine DM, Lucas GM, et al. Observations on a cohort of HIV-infected patients undergoing native renal biopsy. Am J Nephrol. 2008;28:478–486
  35. Estrella M, Fine DM, Gallant JE, et al. HIV type 1 RNA level as a clinical indicator of renal pathology in HIV-infected patients. Clin Infect Dis. 2006;43:377–380
  36. Gervasoni C, Ridolfo AL, Vaccarezza M, et al. Thrombotic microangiopathy in patients with acquired immunodeficiency syndrome before and during the era of introduction of highly active antiretroviral therapy. Clin Infect Dis. 2002;35:1534–1540
  37. Peraldi MN, Maslo C, Akposso K, et al. Acute renal failure in the course of HIV infection: A single-institution retrospective study of ninety-two patients and sixty renal biopsies. Nephrol Dial Transplant. 1999;14:1578–1585
  38. Thompson CE, Damon LE, Ries CA, et al. Thrombotic microangiopathies in the 1980s: Clinical features, response to treatment, and the impact of the human immunodeficiency virus epidemic. Blood. 1992;80:1890–1895
  39. del Arco A, Martinez MA, Pena JM, et al. Thrombotic thrombocytopenic purpura associated with human immunodeficiency virus infection: Demonstration of p24 antigen in endothelial cells. Clin Infect Dis. 1993;17:360–363
  40. Bell WR, Chulay JD, Feinberg JE. Manifestations resembling thrombotic microangiopathy in patients with advanced human immunodeficiency virus (HIV) disease in a cytomegalovirus prophylaxis trial (ACTG 204). Medicine (Baltimore). 1997;76:369–380
  41. Maslo C, Peraldi MN, Desenclos JC, et al. Thrombotic microangiopathy and cytomegalovirus disease in patients infected with human immunodeficiency virus. Clin Infect Dis. 1997;24:350–355
  42. Medou JA, Hilpert F, Toledano D, et al. [Thrombotic microangiopathy and listeria monocytogenes septicemia disclosing human immunodeficiency virus infection]. Ann Med Interne (Paris). 1994;145:503–504
  43. Olszewski AJ, Shapiro JM. Thrombotic thrombocytopenic purpura associated with abacavir in a patient with HIV infection. J Intensive Care Med. 2003;18:156–159
  44. Zaraa I, Maubec E, Valeyrie-Allanore L, et al. [Haemolytic uremic syndrome and acute mesenteric ischemia caused by interferon-alpha-2b in the treatment of Kaposi's sarcoma in an AIDS patient]. Ann Dermatol Venereol. 2007;134:65–67
  45. Cenacchi G, Re MC, Preda P, et al. Human immunodeficiency virus type-1 (HIV-1) infection of endothelial cells in vitro: A virological, ultrastructural and immuno-cytochemical approach. J Submicrosc Cytol Pathol. 1992;24:155–161
  46. Rivera H, Nikitakis NG, Castillo S, et al. Histopathological analysis and demonstration of EBV and HIV p-24 antigen but not CMV expression in labial minor salivary glands of HIV patients affected by diffuse infiltrative lymphocytosis syndrome. J Oral Pathol Med. 2003;32:431–437
  47. Schecter AD, Berman AB, Yi L, et al. HIV envelope gp120 activates human arterial smooth muscle cells. Proc Natl Acad Sci U S A. 2001;98:10142–10147
  48. Ankri A, Bonmarchand M, Coutellier A, et al. Antiphospholipid antibodies are an epiphenomenon in HIV-infected patients. AIDS. 1999;13:1282–1283
  49. Boue F, Dreyfus M, Bridey F, et al. Lupus anticoagulant and HIV infection: A prospective study. AIDS. 1990;4:467–468
  50. Ray PE, Tassi E, Liu XH, et al. Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. Am J Physiol Regul Integr Comp Physiol. 2006;290:R105–R113
  51. Jochimsen F, Gruening W, Arnould T, et al. Thrombotic microangiopathy associated with unusual viral sequences in HIV-1-positive patients. Nephrol Dial Transplant. 2004;19:1129–1135
  52. Franchini M, Montagnana M, Targher G, et al. Reduced von Willebrand factor-cleaving protease levels in secondary thrombotic microangiopathies and other diseases. Semin Thromb Hemost. 2007;33:787–797
  53. Sahud MA, Claster S, Liu L, et al. von Willebrand factor-cleaving protease inhibitor in a patient with human immunodeficiency syndrome-associated thrombotic thrombocytopenic purpura. Br J Haematol. 2002;116:909–911
  54. Alpers CE. Light at the end of the TUNEL: HIV-associated thrombotic microangiopathy. Kidney Int. 2003;63:385–396
  55. Coppo P, Adrie C, Azoulay E, et al. Infectious diseases as a trigger in thrombotic microangiopathies in intensive care unit (ICU) patients?. Intensive Care Med. 2003;29:564–569
  56. Pene F, Vigneau C, Auburtin M, et al. Outcome of severe adult thrombotic microangiopathies in the intensive care unit. Intensive Care Med. 2005;31:71–78
  57. Eknoyan G, Riggs SA. Renal involvement in patients with thrombotic thrombocytopenic purpura. Am J Nephrol. 1986;6:117–131
  58. Badesha PS, Saklayen MG. Hemolytic uremic syndrome as a presenting form of HIV infection. Nephron. 1996;72:472–475
  59. Cruccu V, Parisio E, Pedretti D, et al. HIV-related thrombotic thrombocytopenic purpura (TTP) as first clinical manifestation of infection. Haematologica. 1994;79:277–279
  60. Francois A, Dhib M, Dubois D, et al. Thrombotic microangiopathy (TMA) as the first manifestation of HIV infection. Clin Nephrol. 1993;39:352–354
  61. Sacristan Lista F, Saavedra Alonso AJ, Oliver Morales J, et al. Nephrotic syndrome due to thrombotic microangiopathy (TMA) as the first manifestation of human immunodeficiency virus infection: Recovery before antiretroviral therapy without specific treatment against TMA. Clin Nephrol. 2001;55:404–407
  62. Gupta SK, Mamlin BW, Johnson CS, et al. Prevalence of proteinuria and the development of chronic kidney disease in HIV-infected patients. Clin Nephrol. 2004;61:1–6
  63. Barraclough K, Er L, Ng F, et al. A comparison of the predictive performance of different methods of kidney function estimation in a well-characterized HIV-infected population. Nephron Clin Pract. 2009;111:c39–c48
  64. Rule AD, Cohen SD, Kimmel PL. Editorial comment: Screening for chronic kidney disease requires creatinine references ranges not equations. AIDS Read. 2007;17:262–263
  65. Kimmel PL, Umana WO, Bosch JP. Abnormal urinary protein excretion in HIV-infected patients. Clin Nephrol. 1993;39:17–21
  66. Han TM, Naicker S, Ramdial PK, et al. A cross-sectional study of HIV-seropositive patients with varying degrees of proteinuria in South Africa. Kidney Int. 2006;69:2243–2250
  67. Nakamura Y, Shibuya A, Suzuki H, et al. [Prevalence of chronic kidney disease (CKD) and significant contributors to CKD in HIV-infected patients]. Nippon Jinzo Gakkai Shi. 2008;50:499–505
  68. Szczech LA, Grunfeld C, Scherzer R, et al. Microalbuminuria in HIV infection. AIDS. 2007;21:1003–1009
  69. Gardner LI, Holmberg SD, Williamson JM, et al. Development of proteinuria or elevated serum creatinine and mortality in HIV-infected women. J Acquir Immune Defic Syndr. 2003;32:203–209
  70. Cavalcante MA, Coelho SN, Lacerda HR. Prevalence of persistent proteinuria in stable HIV/AIDS patients and its association with HIV nephropathy. Braz J Infect Dis. 2007;11:456–461
  71. Crowley ST, Cantwell B, Abu-Alfa A, et al. Prevalence of persistent asymptomatic proteinuria in HIV-infected outpatients and lack of correlation with viral load. Clin Nephrol. 2001;55:1–6
  72. Fernando SK, Finkelstein FO, Moore BA, et al. Prevalence of chronic kidney disease in an urban HIV infected population. Am J Med Sci. 2008;335:89–94
  73. Ramezani A, Mohraz M, Banifazl M, et al. Frequency and associated factors of proteinuria in Iranian HIV-positive patients. Int J Infect Dis. 2008;12:490–494
  74. Szczech LA, Gange SJ, van der Horst C, et al. Predictors of proteinuria and renal failure among women with HIV infection. Kidney Int. 2002;61:195–202
  75. Cheung CY, Wong KM, Lee MP, et al. Prevalence of chronic kidney disease in Chinese HIV-infected patients. Nephrol Dial Transplant. 2007;22:3186–3190
  76. Kimmel P. Clinical and immunopathogenic aspects of human immunodeficiency virus associated renal diseases. In:  Nielson EG,  Couser WG editor. Immunologic Renal Diseases. Philadelphia, PA: Lippincott Williams and Wilkins; 2001;p. 1203–1223
  77. Kimmel PL. Immune complex glomerulonephritis associated with HIV infection. In:  Kimmel PL,  Berns J editor. Contemporary Issues in Nephrology. New York, NY: Churchill Livingstone; 1995;p. 77–110
  78. Stokes MB, Chawla H, Brody RI, et al. Immune complex glomerulonephritis in patients coinfected with human immunodeficiency virus and hepatitis C virus. Am J Kidney Dis. 1997;29:514–525
  79. Cheng JT, Anderson HL, Markowitz GS, et al. Hepatitis C virus-associated glomerular disease in patients with human immunodeficiency virus coinfection. J Am Soc Nephrol. 1999;10:1566–1574
  80. Kimmel PL, Phillips TM, Ferreira-Centeno A, et al. Brief report: Idiotypic IgA nephropathy in patients with human immunodeficiency virus infection. N Engl J Med. 1992;327:702–706
  81. Wyatt CM, Morgello S, Katz-Malamed R, et al. The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy. Kidney Int. 2009;75:428–434
  82. Williams DI, Williams DJ, Williams IG, et al. Presentation, pathology, and outcome of HIV associated renal disease in a specialist centre for HIV/AIDS. Sex Transm Infect. 1998;74:179–184
  83. Casanova S, Mazzucco G, Barbiano di Belgiojoso G, et al. Pattern of glomerular involvement in human immunodeficiency virus-infected patients: An Italian study. Am J Kidney Dis. 1995;26:446–453
  84. Lopes GS, Marques LP, Rioja LS, et al. Glomerular disease and human immunodeficiency virus infection in Brazil. Am J Nephrol. 1992;12:281–287
  85. Praditpornsilpa K, Napathorn S, Yenrudi S, et al. Renal pathology and HIV infection in Thailand. Am J Kidney Dis. 1999;33:282–286
  86. Gerntholtz TE, Goetsch SJ, Katz I. HIV-related nephropathy: A South African perspective. Kidney Int. 2006;69:1885–1891
  87. Haas M, Kaul S, Eustace JA. HIV-associated immune complex glomerulonephritis with “lupus-like” features: A clinicopathologic study of 14 cases. Kidney Int. 2005;67:1381–1390
  88. Bene MC, Canton P, Amiel C, et al. Absence of mesangial IgA in AIDS: A postmortem study. Nephron. 1991;58:240–241
  89. Katz A, Bargman JM, Miller DC, et al. IgA nephritis in HIV-positive patients: A new HIV-associated nephropathy?. Clin Nephrol. 1992;38:61–68
  90. Izzedine H, Sene D, Cacoub P, et al. Kidney diseases in HIV/HCV-co-infected patients. AIDS. 2009;23:1219–1226
  91. Tsui J, Vittinghoff E, Anastos K, et al. Hepatitis C seropositivity and kidney function decline among women with HIV: Data from the Women's Interagency HIV Study. Am J Kidney Dis. 2009;54:43–50
  92. Gonzalez R, Vollrath V, Pereira J, et al. Prevalence of hepatitis C virus RNA in hemodialysis patients: Comparison of four antibody assays. Nephron. 1995;69:181–182
  93. di Belgiojoso GB, Genderini A, Bertoli S, et al. Immunoactoid glomerulopathy in a HIV-infected patient: a novel association. Nephrol Dial Transplant. 1996;11:857–859
  94. Haas M, Rajaraman S, Ahuja T, et al. Fibrillary/immunotactoid glomerulonephritis in HIV-positive patients: A report of three cases. Nephrol Dial Transplant. 2000;15:1679–1683
  95. Markowitz GS, Cheng JT, Colvin RB, et al. Hepatitis C viral infection is associated with fibrillary glomerulonephritis and immunotactoid glomerulopathy. J Am Soc Nephrol. 1998;9:2244–2252
  96. Dimitrakopoulos AN, Kordossis T, Hatzakis A, et al. Mixed cryoglobulinemia in HIV-1 infection: The role of HIV-1. Ann Intern Med. 1999;130:226–230
  97. Fabris P, Tositti G, Giordani MT, et al. Prevalence and clinical significance of circulating cryoglobulins in HIV-positive patients with and without co-infection with hepatitis C virus. J Med Virol. 2003;69:339–343
  98. Martin JL, Thomas D, Colindres RE. Immunotactoid glomerulopathy in an HIV-positive African-American man. Am J Kidney Dis. 2003;42:E6–E10
  99. Cohen SD, Kimmel PL. Renal biopsy is necessary for the diagnosis of HIV-associated renal diseases. Nat Clin Pract Nephrol. 2009;5:22–23
  100. Atta MG, Deray G, Lucas GM. Antiretroviral nephrotoxicities. Semin Nephrol. 2008;28:563–575
  101. Daugas E, Rougier JP, Hill G. HAART-related nephropathies in HIV-infected patients. Kidney Int. 2005;67:393–403
  102. Izzedine H, Deray G. The nephrologist in the HAART era. AIDS. 2007;21:409–421
  103. Gupta SK, Eustace JA, Winston JA, et al. Guidelines for the management of chronic kidney disease in HIV-infected patients: Recommendations of the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2005;40:1559–1585
  104. Kimmel PL, Mishkin GJ, Umana WO. Captopril and renal survival in patients with human immunodeficiency virus nephropathy. Am J Kidney Dis. 1996;28:202–208
  105. Wei A, Burns GC, Williams BA, et al. Long-term renal survival in HIV-associated nephropathy with angiotensin-converting enzyme inhibition. Kidney Int. 2003;64:1462–1471
  106. Kimmel PL, Bosch JP, Vassalotti JA. Treatment of human immunodeficiency virus (HIV)-associated nephropathy. Semin Nephrol. 1998;18:446–458
  107. Cohen SD, Chawla LS, Kimmel PL. Acute kidney injury in patients with human immunodeficiency virus infection. Curr Opin Crit Care. 2008;14:647–653
  108. Kao WH, Klag MJ, Meoni LA, et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet. 2008;40:1185–1192
  109. Freedman BI, Hicks PJ, Bostrom MA, et al. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int. 2009;75:736–745
  110. Kopp JB, Smith MW, Nelson GW, et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet. 2008;40:1175–1184
  111. Gorriz JL, Rovira E, Sancho A, et al. IgA nephropathy associated with human immunodeficiency virus infection: antiproteinuric effect of captopril. Nephrol Dial Transplant. 1997;12:2796–2797
  112. Kimmel PL, Abraham AA, Phillips TM. Membranoproliferative glomerulonephritis in a patient treated with interferon-alpha for human immunodeficiency virus infection. Am J Kidney Dis. 1994;24:858–863

PII: S1548-5595(09)00174-8

doi: 10.1053/j.ackd.2009.09.001

Advances in Chronic Kidney Disease
Volume 17, Issue 1 , Pages 83-93 , January 2010

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