Advances in Chronic Kidney Disease
Volume 17, Issue 4 , Pages 341-347 , July 2010

Hypertension and Chronic Kidney Disease in the Elderly

  • Philip A. Kithas

      Affiliations

    • Corresponding Author InformationAddress correspondence to Philip A. Kithas, MD, PhD, Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Medical Center, 500 Foothill Drive, Salt Lake City, 84148.
    • ,
  • Mark A. Supiano

References 

  1. Silva FG. The aging kidney: a review—part 1. Int Urol Nephrol. 2005;37:185–205
  2. Verhave JC, Fesler P, du Cailar G, et al. Elevated pulse pressure is associated with low renal function in elderly patients with isolated systolic hypertension. Hypertension. 2005;45:586–591
  3. Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42:1206–1252
  4. Supiano MA, Hogikyan RV, Sidani MA, et al. Sympathetic nervous system activity and alpha-adrenergic responsiveness in older hypertensive humans. Am J Physiol. 1999;276:E519–E528
  5. Sowers JR, Whaley-Connell A, Epstein M. Narrative Review: The emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Int Med. 2009;150:776–783
  6. Zhou XJ, Rakheja D, Yu X, et al. The aging kidney. Kidney Int. 2008;74:710–720
  7. Brenner BM. Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. Kidney Int. 1983;23:647–655
  8. Hill GS, Heudes D, Bariety J. Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation. Kidney Int. 2003;63:1027–1036
  9. Moser M, Feig PU. Fifty years of thiazide diuretic therapy for hypertension. Arch Intern Med. 2009;169:1851–1856
  10. Goldstein DS, Sharabi Y. Neurogenic orthostatic hypotension, a pathophysiologic approach. Circulation. 2009;119:139–146
  11. Clement DL, De Buyzere ML, De Bacquer DA, et al. Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension. N Engl J Med. 2003;348:2407–2415
  12. Ohkubo T, Hozawa A, Yamaguchi J, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertension. 2002;20:2183–2189
  13. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991;265:3255–3264
  14. Psaty BM, Lumley T, Furberg CD, et al. Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. JAMA. 2003;289:2534–2544
  15. Staessen JA, Fagard R, Lutgarde T, et al. for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet. 1997;350:757–764
  16. Medical Research Council Working Party. MRC trial of treatment of hypertension in older adults: principal results. BMJ. 1992;304:405–412
  17. Beckett NS, Peters R, Fletcher AE, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358:1887–1898
  18. Lewington S, Clarke R, Qizilbash N, et al. Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903–1913
  19. Sacks FM, Svetkey LP, Vollmer WM, et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. N Engl J Med. 2001;344:3–10
  20. Whelton PK, Appel LJ, Espeland MA, et al. Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of non-pharmacologic interventions in the elderly (TONE). JAMA. 1998;279:839–846
  21. Ernst ME, Carter BL, Goerdt CJ, et al. Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension. 2006;47:352–358
  22. Jamerson K, Weber MA, Gl Bakris, et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359:2417–2428
  23. Hansson L, Lindholm LH, Ekbom T, et al. Randomized trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study. Lancet. 1999;354:1751–1756
  24. Pepine CJ, Handberg EM, Cooper-DeHoff RM, et al. A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease: The International Verapamil-Trandalopril Study (INVEST): a randomized controlled trial. JAMA. 2003;290:2805–2816
  25. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002;288:2981–2997
  26. Mahmud A, Feely J. Low-dose quadruple antihypertensive combination: more efficacious than individual agents—a preliminary report. Hypertension. 2007;49:272–275

PII: S1548-5595(10)00075-3

doi: 10.1053/j.ackd.2010.04.003

Advances in Chronic Kidney Disease
Volume 17, Issue 4 , Pages 341-347 , July 2010

Article Tools