Advances in Chronic Kidney Disease
Volume 17, Issue 4 , Pages 302-307 , July 2010

The Aging Kidney: Physiological Changes

  • Jessica R. Weinstein
    • ,
  • Sharon Anderson

      Affiliations

    • Corresponding Author InformationAddress correspondence to Sharon Anderson, MD, Division of Nephrology and Hypertension, Oregon Health and Science University, OHSU Nephrology PP 262, 3314 SW US Veterans Hospital Rd., Portland, OR 97239.

References 

  1. Rodrígues-Puyol D. The aging kidney. Kidney Int. 1998;54:2247–2265
  2. Choudhury D, Levi M. Aging and kidney disease. In:  Brenner BM editors. Brenner & Rector's the Kidney (8th ed). Philadelphia, PA: Saunders; 2008;p. 681–701
  3. Zhou XJ, Rakheja D, Yu X, et al. The aging kidney. Kidney Int. 2008;74:710–720
  4. Davies DF, Shock NW. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest. 1950;29:496–507
  5. Rowe JW, Andres R, Tobin JD, et al. The effect of age on creatinine clearance in men: A cross-sectional and longitudinal study. J Gerontol. 1976;31:155–163
  6. Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038–2047
  7. Lindeman RD, Tobin JD, Shock NW. Association between blood pressure and the rate of decline in renal function with age. Kidney Int. 1984;27:553–557
  8. Fox CS, Larson MG, Leip EP, et al. Predictors of new-onset kidney disease in a community-based population. JAMA. 2004;291:844–850
  9. Kim R, Rotnitsky A, Sparrow D, et al. A longitudinal study of low-level lead exposure and impairment of renal function. The Normative Aging Study. JAMA. 1996;275:1177–1181
  10. Bleyer AJ, Shemanski LR, Burke GL, et al. Tobacco, hypertension, and vascular disease: Risk factors for renal functional decline in an older population. Kidney Int. 2000;57:2072–2079
  11. Fried L, Solomon C, Shlipak M, et al. Inflammatory and prothrombotic markers and the progression of renal disease in elderly individuals. J Am Soc Nephrol. 2004;15:3184–3191
  12. Vlassara H, Torreggiani M, Post JB, et al. Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging. Kidney Int. 2009;76(suppl 114):S3–S11
  13. Foster MC, Hwang S-J, Larson MG, et al. Overweight, obesity, and the development of stage 3 CKD: The Framingham Heart Study. Am J Kidney Dis. 2008;52:39–48
  14. de Boer IH, Katz R, Fried LF, et al. Obesity and change in estimated GFR among older adults. Am J Kidney Dis. 2009;54:1043–1051
  15. Baylis C. Sexual dimorphism in the aging kidney: Differences in the nitric oxide system. Nat Rev Nephrol. 2009;5:384–396
  16. Ishani A, Xue JL, Himmelfarb J, et al. Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2009;20:223–228
  17. Wesson LG. Renal hemodynamics in physiological states. In:  Wesson LG editors. Physiology of the Human Kidney. New York, NY: Grune & Stratton; 1969;p. 96–108
  18. Hollenberg NK, Adams DF, Solomon HS, et al. Senescence and the renal vasculature in normal man. Circ Res. 1974;34:309–316
  19. Anderson S, Rennke HG, Zatz R. Glomerular adaptations with normal aging and with longterm converting enzyme inhibition in the rat. Am J Physiol. 1994;267:F35–F43
  20. Tolbert EM, Weisstuch J, Feiner HD, et al. Onset of glomerular hypertension with aging precedes injury in the spontaneously hypertensive rat. Am J Physiol Renal Physiol. 2000;278:F839–F846
  21. Hoang K, Tan JC, Derby G, et al. Determinants of glomerular hypofiltration in aging humans. Kidney Int. 2003;64:1417–1424
  22. Bolton WK, Benton FR, Maclay JG, et al. Spontaneous glomerular sclerosis in aging Sprague-Dawley rats. Am J Pathol. 1976;85:227–302
  23. Wiggins JE, Goyal M, Sander SK, et al. Podocyte hypertrophy, “adaptation”, and “decompensation” associated with glomerular enlargement and glomerulosclerosis in the aging rat: Prevention by calorie restriction. J Am Soc Nephrol. 2005;16:2953–2966
  24. Cohen MP, Ku L. Age-related changes in sulfation of basement membrane glycosaminoglycans. Exp Gerontol. 1976;18:447–450
  25. Jones CA, Francis ME, Eberhardt MS, et al. Microalbuminuria in the US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2002;39:445–459
  26. Kasiske BL, Umen AJ. The influence of age, sex, race, and body habitus on kidney weight in humans. Arch Pathol Lab Med. 1986;110:55–60
  27. Nyengaard JR, Bendtsen TF. Glomerular number and size in relation to age, kidney and body surface in normal man. Anat Rec. 1992;232:194–201
  28. Emamian SA, Nielsen MB, Pedersen JF, et al. Kidney dimensions at sonography: Correlation with age, sex, and habitus in 665 adult volunteers. AJR Am J Roentgenol. 1993;160:83–86
  29. Tauchi H, Tsuboi K, Okutomi J. Age changes in the human kidney of the different races. Gerontologia. 1971;17:87–97
  30. McLachlan MSF. The ageing kidney. Lancet. 1978;ii:143–146
  31. Goyal VK. Changes with age in the human kidney. Exp Gerontol. 1982;17:321–331
  32. Ljungqvist A, Lagergren C. Normal intrarenal arterial pattern in adult and ageing human kidney. A micro-angiographical and histological study. J Anat. 1962;96:285–300
  33. Takazakura E, Sawabu N, Handa A, et al. Intrarenal vascular changes with age and disease. Kidney Int. 1972;2:224–230
  34. Hill GS, Heudes D, Bariéty J. Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation. Kidney Int. 2003;63:1027–1036
  35. Kaplan C, Pasternack B, Shah H, et al. Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol. 1974;80:227–234
  36. Kappel B, Olsen S. Cortical interstitial tissue and sclerosed glomeruli in the normal human kidney, related to age and sex. A quantitative study. Virchows Arch A Pathol Anat Histol. 1980;387:271–277
  37. Neugarten J, Gallo G, Silbiger S, et al. Glomerulosclerosis in aging humans is not influenced by gender. Am J Kidney Dis. 1999;34:884–888
  38. Wei JY. Age and the cardiovascular system. N Engl J Med. 1992;327:1735–1739
  39. Thomas SE, Anderson S, Gordon KL, et al. Tubulointerstitial disease in aging: Evidence for underlying peritubular capillary damage, a potential role for renal ischemia. J Am Soc Nephrol. 1998;9:231–242
  40. Kang D-H, Anderson S, Kim Y-G, et al. Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and thrombospondin-1 in renal disease. Am J Kidney Dis. 2001;37:601–611
  41. Barton M. Ageing as a determinant of renal and vascular disease: Role of endothelial factors. Nephrol Dial Transplant. 2005;20:485–490
  42. Tank JE, Vora JP, Houghton DC, et al. Altered renal vascular responses in the aging rat kidney. Am J Physiol. 1994;266:F942–F948
  43. Castellani S, Ungar A, Cantini C, et al. Excessive vasoconstriction after stress by the aging kidney: Inadequate prostaglandin modulation of increased endothelin activity. J Lab Clin Med. 1998;132:186–194
  44. Fuaino G, Sund S, Mazza G, et al. Renal hemodynamic response to maximal vasodilating stimulus in healthy older subjects. Kidney Int. 2001;59:1052–1058
  45. Anderson S. Ageing and the renin-angiotensin system. [editorial comment] Nephrol Dial Transplant. 1997;12:1093–1094
  46. Gilliam-Davis S, Payne VS, Kasper SO, et al. Long-term AT1 receptor blockade improves metabolic function and provides renoprotection in Fischer-344 rats. Am J Physiol Heart Circ Physiol. 2007;293:H1327–H1333
  47. Ferder LF, Inserra F, Basso N. Effects of renin-angiotension system blockade in the aging kidney. Exp Gerontol. 2003;38:237–244
  48. Jung FF, Kennefick TM, Ingelfinger JR, et al. Downregulation of the intrarenal renin-angiotensin system in the aging rat. J Am Soc Nephrol. 1995;5:1573–1580
  49. Llorens S, Fernandez AP, Nava E. Cardiovascular and renal alterations on the nitric oxide pathway in spontaneous hypertension and ageing. Clin Hemorheol Microcirc. 2007;37:149–156
  50. Delp MD, Behnke BJ, Spier SA, et al. Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles. J Physiol. 2008;586:1161–1168
  51. Xiong Y, Yuan LW, Deng HW, et al. Elevated serum endogenous inhibitor of nitric oxide synthase and endothelial dysfunction in aged rats. Clin Exp Pharmacol Physiol. 2001;28:842–847
  52. Abuelo JG. Normotensive ischemic acute renal failure. N Engl J Med. 2007;357:797–805
  53. Iseki K, Iseki C, Ikemiya Y, et al. Risk of developing end-stage renal disease in a cohort of mass screening. Kidney Int. 1996;49:800–805
  54. Rogers JL, Mitchell AR, Maric C, et al. Effect of sex hormones on renal estrogen and angiotensin type 2 receptors in female and male rats. Am J Physiol Regul Integr Com Physiol. 2007;292:R794–R799
  55. Fortepiani LA, Yanes L, Zhang H, et al. Role of androgens in mediating renal injury in aging SHR. Hypertension. 2003;42:952–955
  56. Maric C, Sandberg K, Hinojosa-Laborde C. Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17β-estradiol in the aging Dahl salt sensitive rat. J Am Soc Nephrol. 2004;15:1546–1556
  57. Baylis C. Age-dependent glomerular damage in the rat: Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor. J Clin Invest. 1994;94:1823–1829
  58. Moens AL, Kass DA. Tetrahydrobiopterin and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2006;26:2439–2444
  59. Schulze F, Maas R, Freese R, et al. Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects. Eur J Clin Invest. 2005;35:622–626
  60. Ahmed SB, Fisher ND, Hollenberg NK. Gender and the renal nitric oxide synthase system in healthy humans. Clin J Am Soc Nephrol. 2007;2:926–931
  61. Reckelhoff JF, Baylis C. Glomerular metalloprotease activity in the aging rat kidney: Inverse correlation with injury. J Am Soc Nephrol. 1993;3:1835–1838

PII: S1548-5595(10)00079-0

doi: 10.1053/j.ackd.2010.05.002

Advances in Chronic Kidney Disease
Volume 17, Issue 4 , Pages 302-307 , July 2010

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