Long-Term Trends in Allograft Survival

  • Daniel C. Brennan
    Address correspondence to Daniel C. Brennan, MD, Washington University School of Medicine, 6107 Queeny Tower, One Barnes-Jewish Hospital Plaza, St. Louis, MO 63110.
    Washington University School of Medicine, St. Louis, MO.
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      Kidney transplantation has changed dramatically over the past decade. Many advances have occurred that result in shorter hospital stays, decreased acute rejection, less infectious morbidity, and improved long-term allograft survival. Many factors are responsible for the improvement in kidney transplantation, and these factors are discussed in this review. These successes have led to a paradox in the care of the kidney-transplant recipient, however. As the short-term complications are prevented or successfully managed, more patients will develop chronic problems with the function of the allograft.

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